DICER1 RNase IIIb domain mutations trigger widespread miRNA dysregulation and MAPK activation in pediatric thyroid cancer

DICER1 is a highly conserved RNase III endoribonuclease essential for the biogenesis of single-stranded mature microRNAs (miRNAs) from stem-loop precursor miRNAs. Somatic mutations in the RNase IIIb domain of DICER1 impair its ability to generate mature 5p miRNAs and are believed to drive tumorigene...

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Detalles Bibliográficos
Autores principales: Ricarte-Filho, Julio C., Casado-Medrano, Victoria, Reichenberger, Erin, Spangler, Zachary, Scheerer, Michele, Isaza, Amber, Baran, Julia, Patel, Tasleema, MacFarland, Suzanne P., Brodeur, Garrett M., Stewart, Douglas R., Baloch, Zubair, Bauer, Andrew J., Wasserman, Jonathan D., Franco, Aime T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990750/
https://www.ncbi.nlm.nih.gov/pubmed/36896180
http://dx.doi.org/10.3389/fendo.2023.1083382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990750/
https://www.ncbi.nlm.nih.gov/pubmed/36896180
http://dx.doi.org/10.3389/fendo.2023.1083382

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