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DICER1 RNase IIIb domain mutations trigger widespread miRNA dysregulation and MAPK activation in pediatric thyroid cancer

DICER1 is a highly conserved RNase III endoribonuclease essential for the biogenesis of single-stranded mature microRNAs (miRNAs) from stem-loop precursor miRNAs. Somatic mutations in the RNase IIIb domain of DICER1 impair its ability to generate mature 5p miRNAs and are believed to drive tumorigene...

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Detalles Bibliográficos
Autores principales:	Ricarte-Filho, Julio C., Casado-Medrano, Victoria, Reichenberger, Erin, Spangler, Zachary, Scheerer, Michele, Isaza, Amber, Baran, Julia, Patel, Tasleema, MacFarland, Suzanne P., Brodeur, Garrett M., Stewart, Douglas R., Baloch, Zubair, Bauer, Andrew J., Wasserman, Jonathan D., Franco, Aime T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990750/ https://www.ncbi.nlm.nih.gov/pubmed/36896180 http://dx.doi.org/10.3389/fendo.2023.1083382

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