Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by synaptic loss, which can result from dysfunctional microglial phagocytosis and complement activation. However, what signals drive aberrant microglia-mediated engulfment of synapses in AD is unclear. Here we report that secreted phosphoprotein 1 (SPP1/oste...

Descripción completa

Detalles Bibliográficos
Autores principales: De Schepper, Sebastiaan, Ge, Judy Z., Crowley, Gerard, Ferreira, Laís S. S., Garceau, Dylan, Toomey, Christina E., Sokolova, Dimitra, Rueda-Carrasco, Javier, Shin, Sun-Hye, Kim, Jung-Seok, Childs, Thomas, Lashley, Tammaryn, Burden, Jemima J., Sasner, Michael, Sala Frigerio, Carlo, Jung, Steffen, Hong, Soyon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991912/
https://www.ncbi.nlm.nih.gov/pubmed/36747024
http://dx.doi.org/10.1038/s41593-023-01257-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991912/
https://www.ncbi.nlm.nih.gov/pubmed/36747024
http://dx.doi.org/10.1038/s41593-023-01257-z

Ejemplares similares