BET inhibitors rescue anti-PD1 resistance by enhancing TCF7 accessibility in leukemia-derived terminally exhausted CD8(+) T cells

Many acute myeloid leukemia (AML) patients exhibit hallmarks of immune exhaustion, such as increased myeloid-derived suppressor cells, suppressive regulatory T cells and dysfunctional T cells. Similarly, we have identified the same immune-related features, including exhausted CD8(+) T cells (TEx) in...

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Detalles Bibliográficos
Autores principales: Romine, Kyle A., MacPherson, Kevin, Cho, Hyun-jun, Kosaka, Yoko, Flynn, Patrick A., Byrd, Kaelan H., Coy, Jesse L., Newman, Matthew T., Pandita, Ravina, Loo, Christopher P., Scott, Jaime, Adey, Andrew C., Lind, Evan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991923/
https://www.ncbi.nlm.nih.gov/pubmed/36681742
http://dx.doi.org/10.1038/s41375-023-01808-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991923/
https://www.ncbi.nlm.nih.gov/pubmed/36681742
http://dx.doi.org/10.1038/s41375-023-01808-0

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