The PYK2 inhibitor PF-562271 enhances the effect of temozolomide on tumor growth in a C57Bl/6-Gl261 mouse glioma model

BACKGROUND: The development of resistance to temozolomide (TMZ), a standard chemotherapeutic, limits the effective treatment of glioblastoma (GBM). Focal adhesion kinase (FAK) and proline rich tyrosine kinase 2 (Pyk2) regulate proliferation and invasion of GBM cells. We found that TMZ activates FAK...

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Detalles Bibliográficos
Autores principales: Ortiz-Rivera, Jescelica, Nuñez, Rebeca, Kucheryavykh, Yuriy, Kucheryavykh, Lilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992029/
https://www.ncbi.nlm.nih.gov/pubmed/36790653
http://dx.doi.org/10.1007/s11060-023-04260-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992029/
https://www.ncbi.nlm.nih.gov/pubmed/36790653
http://dx.doi.org/10.1007/s11060-023-04260-3

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