The DNA damage response pathway regulates the expression of the immune checkpoint CD47

CD47 is a cell surface ligand expressed on all nucleated cells. It is a unique immune checkpoint protein acting as “don’t eat me” signal to prevent phagocytosis and is constitutively overexpressed in many tumors. However, the underlying mechanism(s) for CD47 overexpression is not clear. Here, we sho...

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Detalles Bibliográficos
Autores principales: Ghantous, Lucy, Volman, Yael, Hefez, Ruth, Wald, Ori, Stern, Esther, Friehmann, Tomer, Chajut, Ayelet, Bremer, Edwin, Elhalel, Michal Dranitzki, Rachmilewitz, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992352/
https://www.ncbi.nlm.nih.gov/pubmed/36882648
http://dx.doi.org/10.1038/s42003-023-04615-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992352/
https://www.ncbi.nlm.nih.gov/pubmed/36882648
http://dx.doi.org/10.1038/s42003-023-04615-6

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