Transposable elements activation triggers necroptosis in mouse embryonic stem cells

Deficiency of the histone H3K9 methyltransferase SETDB1 induces RIPK3-dependent necroptosis in mouse embryonic stem cells (mESCs). However, how necroptosis pathway is activated in this process remains elusive. Here we report that the reactivation of transposable elements (TEs) upon SETDB1 knockout i...

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Detalles Bibliográficos
Autores principales: Jin, Lingmei, He, Jiangping, Feng, Huijian, Li, Sa, Liu, He, Dong, Hongzhi, Hu, MingLi, Huang, Junju, Wu, Haoyu, Chen, Jiekai, Qi, Ling, Wu, Kaixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992707/
https://www.ncbi.nlm.nih.gov/pubmed/36882393
http://dx.doi.org/10.1038/s41419-023-05705-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992707/
https://www.ncbi.nlm.nih.gov/pubmed/36882393
http://dx.doi.org/10.1038/s41419-023-05705-3

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