Cargando…
Two-step structural changes in M3 muscarinic receptor activation rely on the coupled G(q) protein cycle
G protein-coupled receptors (GPCRs) regulate diverse intracellular signaling pathways through the activation of heterotrimeric G proteins. However, the effects of the sequential activation–deactivation cycle of G protein on the conformational changes of GPCRs remains unknown. By developing a Förster...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992711/ https://www.ncbi.nlm.nih.gov/pubmed/36882424 http://dx.doi.org/10.1038/s41467-023-36911-4 |