Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein

Mutant KRAS is a major driver of oncogenesis in a multitude of cancers but remains a challenging target for classical small molecule drugs, motivating the exploration of alternative approaches. Here, we show that aggregation-prone regions (APRs) in the primary sequence of the oncoprotein constitute...

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Detalles Bibliográficos
Autores principales: Janssen, Kobe, Claes, Filip, Van de Velde, Dido, Wehbi, Vanessa L., Houben, Bert, Lampi, Yulia, Nys, Mieke, Khodaparast, Laleh, Khodaparast, Ladan, Louros, Nikolaos, van der Kant, Rob, Verniers, Joffre, Garcia, Teresa, Ramakers, Meine, Konstantoulea, Katerina, Maragkou, Katerina, Duran-Romaña, Ramon, Musteanu, Mónica, Barbacid, Mariano, Scorneaux, Bernard, Beirnaert, Els, Schymkowitz, Joost, Rousseau, Frederic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992772/
https://www.ncbi.nlm.nih.gov/pubmed/36812200
http://dx.doi.org/10.1073/pnas.2214921120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992772/
https://www.ncbi.nlm.nih.gov/pubmed/36812200
http://dx.doi.org/10.1073/pnas.2214921120

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