Conserved reduction of m(6)A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts

N(6)-methyladenosine (m(6)A) regulates mRNA metabolism. While it has been implicated in the development of the mammalian brain and in cognition, the role of m(6)A in synaptic plasticity, especially during cognitive decline, is not fully understood. In this study, we employed methylated RNA immunopre...

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Detalles Bibliográficos
Autores principales: Castro-Hernández, Ricardo, Berulava, Tea, Metelova, Maria, Epple, Robert, Peña Centeno, Tonatiuh, Richter, Julia, Kaurani, Lalit, Pradhan, Ranjit, Sakib, M. Sadman, Burkhardt, Susanne, Ninov, Momchil, Bohnsack, Katherine E., Bohnsack, Markus T., Delalle, Ivana, Fischer, Andre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992849/
https://www.ncbi.nlm.nih.gov/pubmed/36812208
http://dx.doi.org/10.1073/pnas.2204933120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992849/
https://www.ncbi.nlm.nih.gov/pubmed/36812208
http://dx.doi.org/10.1073/pnas.2204933120

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