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Integrating comparative modeling and accelerated simulations reveals conformational and energetic basis of actomyosin force generation
Muscle contraction is performed by arrays of contractile proteins in the sarcomere. Serious heart diseases, such as cardiomyopathy, can often be results of mutations in myosin and actin. Direct characterization of how small changes in the myosin–actin complex impact its force production remains chal...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992861/ https://www.ncbi.nlm.nih.gov/pubmed/36802417 http://dx.doi.org/10.1073/pnas.2215836120 |