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Integrating comparative modeling and accelerated simulations reveals conformational and energetic basis of actomyosin force generation

Muscle contraction is performed by arrays of contractile proteins in the sarcomere. Serious heart diseases, such as cardiomyopathy, can often be results of mutations in myosin and actin. Direct characterization of how small changes in the myosin–actin complex impact its force production remains chal...

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Detalles Bibliográficos
Autores principales: Ma, Wen, You, Shengjun, Regnier, Michael, McCammon, J. Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9992861/
https://www.ncbi.nlm.nih.gov/pubmed/36802417
http://dx.doi.org/10.1073/pnas.2215836120

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