Assay development and inhibition of the Mt-DprE2 essential reductase from Mycobacterium tuberculosis

DprE2 is an essential enzyme in the synthesis of decaprenylphosphoryl-β-d-arabinofuranose (DPA) and subsequently arabinogalactan, and is a significant new drug target for M. tuberculosis . Two compounds from the GSK-177 box set, GSK301A and GSK032A, were identified through Mt-DprE2-target overexpres...

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Detalles Bibliográficos
Autores principales: Batt, Sarah M., Toth, Szilvi, Rodriguez, Beatriz, Abrahams, Katherine A., Veerapen, Natacha, Chiodarelli, Giacomo, Cox, Liam R., Moynihan, Patrick J., Lelievre, Joel, Fütterer, Klaus, Besra, Gurdyal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2023
Materias:
Antimicrobials and AMR
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993113/
https://www.ncbi.nlm.nih.gov/pubmed/36748627
http://dx.doi.org/10.1099/mic.0.001288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993113/
https://www.ncbi.nlm.nih.gov/pubmed/36748627
http://dx.doi.org/10.1099/mic.0.001288

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