Adaptation of Pseudomonas aeruginosa biofilms to tobramycin and the quorum sensing inhibitor C-30 during experimental evolution requires multiple genotypic and phenotypic changes

In the present study we evaluated the fitness, antimicrobial susceptibility, metabolic activity, gene expression, in vitro production of virulence factors and in vivo virulence of experimentally evolved Pseudomonas aeruginosa PAO1. These strains were previously evolved in the presence of tobramycin...

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Detalles Bibliográficos
Autores principales: Bové, Mona, Kolpen, Mette, Lichtenberg, Mads, Bjarnsholt, Thomas, Coenye, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2023
Materias:
Microbial Evolution
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993117/
https://www.ncbi.nlm.nih.gov/pubmed/36748633
http://dx.doi.org/10.1099/mic.0.001278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993117/
https://www.ncbi.nlm.nih.gov/pubmed/36748633
http://dx.doi.org/10.1099/mic.0.001278

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