miR-132-3p regulates antibody-mediated complement-dependent cytotoxicity in colon cancer cells by directly targeting CD55

The overexpression of membrane-bound complement regulatory proteins (mCRPs) on tumour cells helps them survive complement attacks by suppressing antibody-mediated complement-dependent cytotoxicity (CDC). Consequently, mCRP overexpression limits monoclonal antibody drug immune efficacy. CD55, an mCRP...

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Detalles Bibliográficos
Autores principales: Fan, Yu, Liao, Juan, Wang, Yu, Wang, Zhu, Zheng, Hong, Wang, Yanping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Cancer Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993456/
https://www.ncbi.nlm.nih.gov/pubmed/36571232
http://dx.doi.org/10.1093/cei/uxac120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993456/
https://www.ncbi.nlm.nih.gov/pubmed/36571232
http://dx.doi.org/10.1093/cei/uxac120

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