Vicinal stereocenters via asymmetric allylic alkylation and Cope rearrangement: a straightforward route to functionally and stereochemically rich heterocycles

An asymmetric allylic alkylation/Cope rearrangement (AAA/[3,3]) capable of stereoselectively constructing vicinal stereocenters has been developed. Strategically integrated 4-methylation on the 3,3-dicyano-1,5-diene controls stereoselectivity and drives Cope rearrangement equilibrium in the forward...

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Detalles Bibliográficos
Autores principales: Nilova, Aleksandra, Mannchen, Michael D., Noel, Abdias N., Semenova, Evgeniya, Grenning, Alexander J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993902/
https://www.ncbi.nlm.nih.gov/pubmed/36908968
http://dx.doi.org/10.1039/d2sc07021a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9993902/
https://www.ncbi.nlm.nih.gov/pubmed/36908968
http://dx.doi.org/10.1039/d2sc07021a

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