Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design

The Petasis borono-Mannich reaction was employed for an alternative entry towards three-branched cereblon ligands. Such compounds are capabable of making multiple interactions with the protein surface and possess a suitable linker exit vector. The high-affinity ligands were used to assemble prototyp...

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Detalles Bibliográficos
Autores principales: Kuchta, Robert, Heim, Christopher, Herrmann, Alexander, Maiwald, Samuel, Ng, Yuen Lam Dora, Sosič, Izidor, Keuler, Tim, Krönke, Jan, Gütschow, Michael, Hartmann, Marcus D., Steinebach, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994103/
https://www.ncbi.nlm.nih.gov/pubmed/36908700
http://dx.doi.org/10.1039/d2cb00223j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994103/
https://www.ncbi.nlm.nih.gov/pubmed/36908700
http://dx.doi.org/10.1039/d2cb00223j

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