A Conformational Change in the N Terminus of SLC38A9 Signals mTORC1 Activation

mTORC1 is a central hub that integrates environmental cues, such as cellular stresses and nutrient availability to modulate metabolism and cellular responses. Recently, SLC38A9, a lysosomal amino acid transporter, emerged as a sensor for luminal arginine and as an activator of mTORC1. The amino acid...

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Detalles Bibliográficos
Autores principales: Lei, Hsiang-Ting, Mu, Xuelang, Hattne, Johan, Gonen, Tamir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994763/
https://www.ncbi.nlm.nih.gov/pubmed/33296665
http://dx.doi.org/10.1016/j.str.2020.11.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994763/
https://www.ncbi.nlm.nih.gov/pubmed/33296665
http://dx.doi.org/10.1016/j.str.2020.11.014

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