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A Conformational Change in the N Terminus of SLC38A9 Signals mTORC1 Activation
mTORC1 is a central hub that integrates environmental cues, such as cellular stresses and nutrient availability to modulate metabolism and cellular responses. Recently, SLC38A9, a lysosomal amino acid transporter, emerged as a sensor for luminal arginine and as an activator of mTORC1. The amino acid...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994763/ https://www.ncbi.nlm.nih.gov/pubmed/33296665 http://dx.doi.org/10.1016/j.str.2020.11.014 |