Hierarchical sequence-affinity landscapes shape the evolution of breadth in an anti-influenza receptor binding site antibody

Broadly neutralizing antibodies (bnAbs) that neutralize diverse variants of a particular virus are of considerable therapeutic interest. Recent advances have enabled us to isolate and engineer these antibodies as therapeutics, but eliciting them through vaccination remains challenging, in part due t...

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Detalles Bibliográficos
Autores principales: Phillips, Angela M, Maurer, Daniel P, Brooks, Caelan, Dupic, Thomas, Schmidt, Aaron G, Desai, Michael M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995116/
https://www.ncbi.nlm.nih.gov/pubmed/36625542
http://dx.doi.org/10.7554/eLife.83628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995116/
https://www.ncbi.nlm.nih.gov/pubmed/36625542
http://dx.doi.org/10.7554/eLife.83628

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