Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains

The design of compounds that can discriminate between closely related target proteins remains a central challenge in drug discovery. Specific therapeutics targeting the highly conserved myosin motor family are urgently needed as mutations in at least six of its members cause numerous diseases. Allos...

Descripción completa

Detalles Bibliográficos
Autores principales: Meller, Artur, Lotthammer, Jeffrey M, Smith, Louis G, Novak, Borna, Lee, Lindsey A, Kuhn, Catherine C, Greenberg, Lina, Leinwand, Leslie A, Greenberg, Michael J, Bowman, Gregory R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995120/
https://www.ncbi.nlm.nih.gov/pubmed/36705568
http://dx.doi.org/10.7554/eLife.83602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995120/
https://www.ncbi.nlm.nih.gov/pubmed/36705568
http://dx.doi.org/10.7554/eLife.83602

Ejemplares similares