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Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains
The design of compounds that can discriminate between closely related target proteins remains a central challenge in drug discovery. Specific therapeutics targeting the highly conserved myosin motor family are urgently needed as mutations in at least six of its members cause numerous diseases. Allos...
Autores principales: | Meller, Artur, Lotthammer, Jeffrey M, Smith, Louis G, Novak, Borna, Lee, Lindsey A, Kuhn, Catherine C, Greenberg, Lina, Leinwand, Leslie A, Greenberg, Michael J, Bowman, Gregory R |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995120/ https://www.ncbi.nlm.nih.gov/pubmed/36705568 http://dx.doi.org/10.7554/eLife.83602 |
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