Uracil-DNA glycosylase efficiency is modulated by substrate rigidity

Uracil DNA-glycosylase (UNG) is a DNA repair enzyme that removes the highly mutagenic uracil lesion from DNA using a base flipping mechanism. Although this enzyme has evolved to remove uracil from diverse sequence contexts, UNG excision efficiency depends on DNA sequence. To provide the molecular ba...

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Detalles Bibliográficos
Autores principales: Orndorff, Paul B., Poddar, Souvik, Owens, Aerial M., Kumari, Nikita, Ugaz, Bryan T., Amin, Samrat, Van Horn, Wade D., van der Vaart, Arjan, Levitus, Marcia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995336/
https://www.ncbi.nlm.nih.gov/pubmed/36890276
http://dx.doi.org/10.1038/s41598-023-30620-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995336/
https://www.ncbi.nlm.nih.gov/pubmed/36890276
http://dx.doi.org/10.1038/s41598-023-30620-0

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