Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration

Frontotemporal lobar degeneration with MAPT pathogenic variants (FTLD-MAPT) has heterogeneous tau pathological inclusions postmortem, consisting of three-repeat (3R) or four-repeat (4R) tau isoforms, or a combination (3R + 4R). Here, we studied grey matter tau burden, its relation to neuronal degene...

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Detalles Bibliográficos
Autores principales: Giannini, Lucia A. A., Ohm, Daniel T., Rozemuller, Annemieke J. M., Dratch, Laynie, Suh, EunRan, van Deerlin, Vivianna M., Trojanowski, John Q., Lee, Edward B., van Swieten, John C., Grossman, Murray, Seelaar, Harro, Irwin, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995405/
https://www.ncbi.nlm.nih.gov/pubmed/36066634
http://dx.doi.org/10.1007/s00401-022-02487-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995405/
https://www.ncbi.nlm.nih.gov/pubmed/36066634
http://dx.doi.org/10.1007/s00401-022-02487-4

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