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Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration
Frontotemporal lobar degeneration with MAPT pathogenic variants (FTLD-MAPT) has heterogeneous tau pathological inclusions postmortem, consisting of three-repeat (3R) or four-repeat (4R) tau isoforms, or a combination (3R + 4R). Here, we studied grey matter tau burden, its relation to neuronal degene...
Autores principales: | Giannini, Lucia A. A., Ohm, Daniel T., Rozemuller, Annemieke J. M., Dratch, Laynie, Suh, EunRan, van Deerlin, Vivianna M., Trojanowski, John Q., Lee, Edward B., van Swieten, John C., Grossman, Murray, Seelaar, Harro, Irwin, David J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995405/ https://www.ncbi.nlm.nih.gov/pubmed/36066634 http://dx.doi.org/10.1007/s00401-022-02487-4 |
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