A screen for MeCP2-TBL1 interaction inhibitors using a luminescence-based assay

Understanding the molecular pathology of neurodevelopmental disorders should aid the development of therapies for these conditions. In MeCP2 duplication syndrome (MDS)—a severe autism spectrum disorder—neuronal dysfunction is caused by increased levels of MeCP2. MeCP2 is a nuclear protein that binds...

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Detalles Bibliográficos
Autores principales: Alexander-Howden, Beatrice, Zhang, Li, van der Sloot, Almer M., Tollis, Sylvain, St-Cyr, Daniel J., Sicheri, Frank, Bird, Adrian P., Tyers, Mike, Lyst, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995496/
https://www.ncbi.nlm.nih.gov/pubmed/36890145
http://dx.doi.org/10.1038/s41598-023-29915-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995496/
https://www.ncbi.nlm.nih.gov/pubmed/36890145
http://dx.doi.org/10.1038/s41598-023-29915-z

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