Lack of concentration-dependent local toxicity of highly concentrated (5%) versus conventional 0.5% bupivacaine following musculoskeletal surgery in a rat model

PURPOSE: Various sustained-release formulations incorporate high bupivacaine concentrations but data on local toxicity is lacking. This study explores local toxic effects of highly concentrated (5%) bupivacaine compared to clinically used concentrations in vivo following skeletal surgery, to assess...

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Detalles Bibliográficos
Autores principales: Steverink, Jasper G., van Tol, Floris R., Bruins, Suzanne, Smorenburg, Andre J., Tryfonidou, Marianna A., Oosterman, Bas J., van Dijk, Marijke R., Malda, Jos, Verlaan, Jorrit-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995632/
https://www.ncbi.nlm.nih.gov/pubmed/36884187
http://dx.doi.org/10.1186/s40634-023-00591-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995632/
https://www.ncbi.nlm.nih.gov/pubmed/36884187
http://dx.doi.org/10.1186/s40634-023-00591-2

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