Cargando…

Neuroprotective effect of Dl-3-n-butylphthalide against ischemia–reperfusion injury is mediated by ferroptosis regulation via the SLC7A11/GSH/GPX4 pathway and the attenuation of blood–brain barrier disruption

BACKGROUND: Stroke is one of the most severe diseases worldwide, resulting in physical and mental problems. Dl-3-n-butylphthalide, a compound derived from celery seed, has been approved for treating ischemic stroke in China. No study has evaluated how Dl-3-n-butylphthalide affects the ferroptosis SL...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Shuangli, Li, Xuewei, Li, Yutian, Li, Xiangling, Lv, E., Zhang, Xiaojun, Shi, Youkui, Wang, Yanqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Aging Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995665/ https://www.ncbi.nlm.nih.gov/pubmed/36909944 http://dx.doi.org/10.3389/fnagi.2023.1028178

Ejemplares similares

1,25-D3 attenuates cerebral ischemia injury by regulating mitochondrial metabolism via the AMPK/AKT/GSK3β pathway
por: Li, Yutian, et al.
Publicado: (2022)

Dl-3-n-Butylphthalide Exerts Dopaminergic Neuroprotection Through Inhibition of Neuroinflammation
por: Chen, Yajing, et al.
Publicado: (2019)

Corrigendum: Dl-3-n-Butylphthalide Exerts Dopaminergic Neuroprotection Through Inhibition of Neuroinflammation
por: Chen, Yajing, et al.
Publicado: (2021)

Pien-Tze-Huang prevents hepatocellular carcinoma by inducing ferroptosis via inhibiting SLC7A11-GSH-GPX4 axis
por: Yan, Xiangying, et al.
Publicado: (2023)

Resveratrol reduces ROS-induced ferroptosis by activating SIRT3 and compensating the GSH/GPX4 pathway
por: Wang, Xingjie, et al.
Publicado: (2023)

DL-3-n-butylphthalide alleviates motor disturbance by suppressing ferroptosis in a rat model of Parkinson’s disease
por: Hu, Chun-Bo, et al.
Publicado: (2022)

Regulation of the p53‑mediated ferroptosis signaling pathway in cerebral ischemia stroke (Review)
por: Xu, Shuangli, et al.
Publicado: (2023)

System X(c) (−)/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy
por: Li, Feng-Jiao, et al.
Publicado: (2022)

Protective effects of dl-3n-butylphthalide against diffuse brain injury
por: Zhao, Yaning, et al.
Publicado: (2013)

Effect of Dl-3-n-butylphthalide on mitochondrial Cox7c in models of cerebral ischemia/reperfusion injury
por: Jia, Jingjing, et al.
Publicado: (2023)

Lipid Peroxides Mediated Ferroptosis in Electromagnetic Pulse-Induced Hippocampal Neuronal Damage via Inhibition of GSH/GPX4 Axis
por: Lai, Yunfei, et al.
Publicado: (2022)

Involvement of FSP1-CoQ(10)-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis
por: Yang, Ming, et al.
Publicado: (2022)

Dl-3-n-butylphthalide Reduces Neurovascular Inflammation and Ischemic Brain Injury in Mice
por: Yang, Chun-Sheng, et al.
Publicado: (2019)

Treadmill Training Reduces Cerebral Ischemia-Reperfusion Injury by Inhibiting Ferroptosis through Activation of SLC7A11/GPX4
por: Liu, Tongye, et al.
Publicado: (2022)

Capsaicin induces ferroptosis of NSCLC by regulating SLC7A11/GPX4 signaling in vitro
por: Liu, Xiao-Yan, et al.
Publicado: (2022)

Dl-3-n-butylphthalide regulates cholinergic dysfunction in chronic cerebral hypoperfusion rats
por: Sun, Yanan, et al.
Publicado: (2020)

Neuroprotective Effects of dl-3-n-Butylphthalide against Doxorubicin-Induced Neuroinflammation, Oxidative Stress, Endoplasmic Reticulum Stress, and Behavioral Changes
por: Liao, Dehua, et al.
Publicado: (2018)

Dl-3-n-butylphthalide exerts neuroprotective effects by modulating hypoxia-inducible factor 1-alpha ubiquitination to attenuate oxidative stress-induced apoptosis
por: Li, Shuai, et al.
Publicado: (2023)

Inhibiting of GRASP65 Phosphorylation by DL-3-N-Butylphthalide Protects against Cerebral Ischemia-Reperfusion Injury via ERK Signaling
por: Zhu, Bei-lei, et al.
Publicado: (2018)

Dl-3-n-Butylphthalide promotes neovascularization and neurological recovery in a rat model of intracerebral hemorrhage
por: Tu, Ewen, et al.
Publicado: (2020)

NeuroD4 converts glioblastoma cells into neuron-like cells through the SLC7A11-GSH-GPX4 antioxidant axis
por: Wang, Hao, et al.
Publicado: (2023)

Neuroprotective mechanisms of 3-n-butylphthalide in neurodegenerative diseases
por: Luo, Rixin, et al.
Publicado: (2019)

Dl-3-n-Butylphthalide Reduces Cognitive Deficits and Alleviates Neuropathology in P301S Tau Transgenic Mice
por: Chang, Yanmin, et al.
Publicado: (2021)

Effects of Dl-3-n-butylphthalide on cognitive functions and blood–brain barrier in chronic cerebral hypoperfusion rats
por: Ma, Yang, et al.
Publicado: (2023)

Dl-3-n-Butylphthalide Treatment Enhances Hemodynamics and Ameliorates Memory Deficits in Rats with Chronic Cerebral Hypoperfusion
por: Xiong, Zhilin, et al.
Publicado: (2017)

Dl‐3‐N‐butylphthalide promotes angiogenesis and upregulates sonic hedgehog expression after cerebral ischemia in rats
por: Zhou, Pan‐Ting, et al.
Publicado: (2019)

Dl-3-n-Butylphthalide Ameliorates Diabetic Nephropathy by Ameliorating Excessive Fibrosis and Podocyte Apoptosis
por: Xu, Jingyu, et al.
Publicado: (2021)

SLC7A11/GPX4 Inactivation-Mediated Ferroptosis Contributes to the Pathogenesis of Triptolide-Induced Cardiotoxicity
por: Liu, Xian, et al.
Publicado: (2022)

Corrigendum: Dl-3-n-Butylphthalide Reduces Cognitive Deficits and Alleviates Neuropathology in P301S Tau Transgenic Mice
por: Chang, Yanmin, et al.
Publicado: (2021)

DL-3-n-butylphthalide delays the onset and progression of diabetic cataract by inhibiting oxidative stress in rat diabetic model
por: Wang, Fuxu, et al.
Publicado: (2016)

Correction to: Effects of Dl-3‑n‑butylphthalide on cognitive functions and blood–brain barrier in chronic cerebral hypoperfusion rats
por: Ma, Yang, et al.
Publicado: (2023)

DL-3-n-butylphthalide for acute ischemic stroke: An updated systematic review and meta-analysis of randomized controlled trials
por: Wang, Huan, et al.
Publicado: (2022)

Dl-3-n-Butylphthalide (NBP) Mitigates Muscular Injury Induced by Limb Ischemia/Reperfusion in Mice through the HMGB1/TLR4/NF-κB Pathway
por: Sun, Huanhuan, et al.
Publicado: (2022)

Effects of Dl-3-n-butylphthalide on Cerebral Ischemia Infarction in Rat Model by Mass Spectrometry Imaging
por: Liu, Run-Zhe, et al.
Publicado: (2017)

DL-3-n-butylphthalide Increases Collateriogenesis and Functional Recovery after Focal Ischemic Stroke in Mice
por: Wei, Zheng Zachory, et al.
Publicado: (2021)

Dl-3-n-butylphthalide attenuates brain injury caused by cortical infarction accompanied by cranial venous drainage disturbance
por: Song, Kangping, et al.
Publicado: (2022)

Tetrandrine citrate suppresses lung adenocarcinoma growth via SLC7A11/GPX4-mediated ferroptosis
por: Mo, Xiaocong, et al.
Publicado: (2023)

Resveratrol Alleviates Diabetic Periodontitis-Induced Alveolar Osteocyte Ferroptosis Possibly via Regulation of SLC7A11/GPX4
por: Li, Yue, et al.
Publicado: (2023)

Licochalcone A Induces Ferroptosis in Hepatocellular Carcinoma via Reactive Oxygen Species Activated by the SLC7A11/GPX4 Pathway
por: Zhang, Jin-Xin, et al.
Publicado: (2023)

DL-3n-Butylphthalide Improves Blood–Brain Barrier Integrity in Rat After Middle Cerebral Artery Occlusion
por: Mamtilahun, Muyassar, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_omtedu66i2hpi1cpt2ee7kb5rk