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Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1

Ca(2+) release-activated Ca(2+) (CRAC) channels, indispensable for the immune system and various other human body functions, consist of two transmembrane (TM) proteins, the Ca(2+)-sensor STIM1 in the ER membrane and the Ca(2+) ion channel Orai1 in the plasma membrane. Here we employ genetic code exp...

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Detalles Bibliográficos
Autores principales: Maltan, Lena, Weiß, Sarah, Najjar, Hadil, Leopold, Melanie, Lindinger, Sonja, Höglinger, Carmen, Höbarth, Lorenz, Sallinger, Matthias, Grabmayr, Herwig, Berlansky, Sascha, Krivic, Denis, Hopl, Valentina, Blaimschein, Anna, Fahrner, Marc, Frischauf, Irene, Tiffner, Adéla, Derler, Isabella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995687/
https://www.ncbi.nlm.nih.gov/pubmed/36890174
http://dx.doi.org/10.1038/s41467-023-36458-4