Lipid environment determines the drug-stimulated ATPase activity of P-glycoprotein

P-glycoprotein (Pgp) is a multidrug transporter that uses the energy from ATP binding and hydrolysis to export from cells a wide variety of hydrophobic compounds including anticancer drugs, and mediates the bioavailability and pharmacokinetics of many drugs. Lipids and cholesterol have been shown to...

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Detalles Bibliográficos
Autores principales: Tran, Nghi N. B., Bui, A. T. A., Jaramillo-Martinez, Valeria, Weber, Joachim, Zhang, Qinghai, Urbatsch, Ina L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995911/
https://www.ncbi.nlm.nih.gov/pubmed/36911528
http://dx.doi.org/10.3389/fmolb.2023.1141081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995911/
https://www.ncbi.nlm.nih.gov/pubmed/36911528
http://dx.doi.org/10.3389/fmolb.2023.1141081

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