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Sotatercept analog improves cardiopulmonary remodeling and pulmonary hypertension in experimental left heart failure

Pulmonary hypertension due to left heart disease (PH-LHD) is the most frequent manifestation of PH but lacks any approved treatment. Activin receptor type IIA-Fc fusion protein (ActRIIA-Fc) was found previously to be efficacious in experimental and human pulmonary arterial hypertension (PAH). Here w...

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Detalles Bibliográficos
Autores principales: Joshi, Sachindra R., Atabay, Elif Karaca, Liu, Jun, Ding, Yan, Briscoe, Steven D., Alexander, Mark J., Andre, Patrick, Kumar, Ravindra, Li, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996114/
https://www.ncbi.nlm.nih.gov/pubmed/36910526
http://dx.doi.org/10.3389/fcvm.2023.1064290