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BMAL1-TTK-H2Bub1 loop deficiency contributes to impaired BM-MSC-mediated bone formation in senile osteoporosis

During the aging process, the reduced osteogenic differentiation of bone marrow mesenchymal stem cells (BM-MSCs) results in decreased bone formation, which contributes to senile osteoporosis. Previous studies have confirmed that interrupted circadian rhythm plays an indispensable role in age-related...

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Detalles Bibliográficos
Autores principales: Jinteng, Li, Peitao, Xu, Wenhui, Yu, Guiwen, Ye, Feng, Ye, Xiaojun, Xu, Zepeng, Su, Jiajie, Lin, Yunshu, Che, Zhaoqiang, Zhang, Yipeng, Zeng, Zhikun, Li, Pei, Feng, Qian, Cao, Dateng, Li, Zhongyu, Xie, Yanfeng, Wu, Huiyong, Shen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996134/
https://www.ncbi.nlm.nih.gov/pubmed/36910712
http://dx.doi.org/10.1016/j.omtn.2023.02.014