Safety, tolerability, and immunogenicity of inactivated poliovirus vaccine with or without E.coli double mutant heat-labile toxin (dmLT) adjuvant in healthy adults; a phase 1 randomized study

BACKGROUND: Inactivated trivalent poliovirus vaccine (IPV) induces humoral immunity, which protects against paralytic poliomyelitis but does not induce sufficient mucosal immunity to block intestinal infection. We assessed the intestinal immunity in healthy adults in Belgium conferred by a co-formul...

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Detalles Bibliográficos
Autores principales: Erdem, Rahsan, De Coster, Ilse, Withanage, Kanchanamala, Mercer, Laina D., Marchant, Arnaud, Taton, Martin, Cools, Nathalie, Lion, Eva, Cassels, Fred, Higgins, Deborah, Ivinson, Karen, Locke, Emily, Mahmood, Kutub, Wright, Peter F., Gast, Chris, White, Jessica A., Ackerman, Margaret E., Konopka-Anstadt, Jennifer L., Mainou, Bernardo A., Van Damme, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996288/
https://www.ncbi.nlm.nih.gov/pubmed/36746739
http://dx.doi.org/10.1016/j.vaccine.2023.01.048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996288/
https://www.ncbi.nlm.nih.gov/pubmed/36746739
http://dx.doi.org/10.1016/j.vaccine.2023.01.048

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