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Characterization of two distinct neutrophil serine protease–binding modes within a Staphylococcus aureus innate immune evasion protein family

Extracellular adherence protein domain (EAPs) proteins are a class of innate immune evasion proteins secreted by the human pathogen Staphylococcus aureus. EAPs are potent and selective inhibitors of cathepsin-G (CG) and neutrophil elastase (NE), which are the two most abundant neutrophil serine prot...

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Detalles Bibliográficos
Autores principales: Gido, Carson D., Herdendorf, Timothy J., Geisbrecht, Brian V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996362/
https://www.ncbi.nlm.nih.gov/pubmed/36736422
http://dx.doi.org/10.1016/j.jbc.2023.102969