Cargando…

IL-10 modified mRNA monotherapy prolongs survival after composite facial allografting through the induction of mixed chimerism

Vascularized composite allotransplantation has great potential in face transplantation by supporting functional restoration following tissue grafting. However, the need for lifelong administration of immunosuppressive drugs still limits its wide use. Modified mRNA (modRNA) technology provides an eff...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aviña, Ana Elena, De Paz, Dante, Huang, Shu-Chun, Chen, Kuan-Hung, Chang, Yun-Ching, Lee, Chin-Ming, Lin, Chia-Hsien, Wei, Fu-Chan, Wang, Aline Yen Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996371/ https://www.ncbi.nlm.nih.gov/pubmed/36910717 http://dx.doi.org/10.1016/j.omtn.2023.02.016

Ejemplares similares

The Mandible Ameliorates Facial Allograft Rejection and Is Associated with the Development of Regulatory T Cells and Mixed Chimerism
por: De Paz, Dante, et al.
Publicado: (2021)

Donor-Specific Regulatory T Cells Acquired from Tolerant Mice Bearing Cardiac Allograft Promote Mixed Chimerism and Prolong Intestinal Allograft Survival
por: Shen, Xiao-Fei, et al.
Publicado: (2016)

Prolonged Survival of Subcutaneous Allogeneic Islet Graft by Donor Chimerism without Immunosuppressive Treatment
por: Hsu, Brend Ray-Sea, et al.
Publicado: (2017)

Anti-IL-6 eluting immunomodulatory biomaterials prolong skin allograft survival
por: Uehara, Mayuko, et al.
Publicado: (2019)

Chimerism-Based Experimental Models for Tolerance Induction in Vascularized Composite Allografts: Cleveland Clinic Research Experience
por: Siemionow, Maria, et al.
Publicado: (2013)

Improving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite Allografts
por: Huang, Wei-Chao, et al.
Publicado: (2012)

Donor Recipient Chimeric Cells Induce Chimerism and Extend Survival of Vascularized Composite Allografts
por: Cwykiel, Joanna, et al.
Publicado: (2021)

Subcutaneous administration of a neutralizing IL‐1β antibody prolongs limb allograft survival
por: Hautz, Theresa, et al.
Publicado: (2018)

IL‐10 producing type 2 innate lymphoid cells prolong islet allograft survival
por: Huang, Qingsong, et al.
Publicado: (2020)

Monotherapy With Anti-CD70 Antibody Causes Long-Term Mouse Cardiac Allograft Acceptance With Induction of Tolerogenic Dendritic Cells
por: Zhao, Jing, et al.
Publicado: (2021)

Shikonin Prolongs Allograft Survival via Induction of CD4(+)FoxP3(+) Regulatory T Cells
por: Zeng, Qiaohuang, et al.
Publicado: (2019)

Specific immunosuppression by mixed chimerism with bone marrow transplantation after Staphylococcal Enterotoxin B pretreatment could prolong corneal allograft survival in mice
por: Zhang, Yingnan, et al.
Publicado: (2012)

A case of facial composite tissue allograft rejection
por: Yan, Di, et al.
Publicado: (2020)

HLA-G Dimers in the Prolongation of Kidney Allograft Survival
por: Ezeakile, Maureen, et al.
Publicado: (2014)

Prolongation of allograft survival by passenger donor regulatory T cells
por: Harper, Ines G., et al.
Publicado: (2019)

Higher efficacy of anti-IL-6/IL-21 combination therapy compared to monotherapy in the induction phase of Th17-driven experimental arthritis
por: Roeleveld, Debbie M., et al.
Publicado: (2017)

Chimerism-Based Tolerance to Kidney Allografts in Humans: Novel Insights and Future Perspectives
por: Podestà, Manuel Alfredo, et al.
Publicado: (2022)

Dendritic Cells Transduced with Single Immunoglobulin IL-1-Related Receptor Exhibit Immature Properties and Prolong Islet Allograft Survival
por: Xue, Zhicheng, et al.
Publicado: (2017)

Modulation of LIGHT-HVEM Costimulation Prolongs Cardiac Allograft Survival
por: Ye, Qunrui, et al.
Publicado: (2002)

Mechanisms of Tolerance Induction by Hematopoietic Chimerism: The Immune Perspective
por: Yolcu, Esma S., et al.
Publicado: (2017)

Enhancing Face Transplant Outcomes: Fundamental Principles of Facial Allograft Revision
por: Diep, Gustave K., et al.
Publicado: (2020)

Thioredoxin Priming Prolongs Lung Allograft Survival by Promoting Immune Tolerance
por: Hu, Hanbo, et al.
Publicado: (2015)

HLA-B Matching Prolongs Allograft Survival in Islet Cell Transplantation
por: Lemos, Joana R. N., et al.
Publicado: (2023)

Natural Killer Cell Subsets and IL-2, IL-15, and IL-18 Genes Expressions in Chronic Kidney Allograft Dysfunction and Graft Function in Kidney Allograft Recipients
por: Assadiasl, S., et al.
Publicado: (2016)

Facial Cushioning during Prolonged Surgery in the Upper Torso
por: Bank, Jonathan, et al.
Publicado: (2014)

Fractional CO(2) Laser Resurfacing as Monotherapy in the Treatment of Atrophic Facial Acne Scars
por: Majid, Imran, et al.
Publicado: (2014)

Interleukin 21 (IL-21) regulates chronic allograft vasculopathy (CAV) in murine heart allograft rejection
por: Khattar, Mithun, et al.
Publicado: (2019)

Tregs and Mixed Chimerism as Approaches for Tolerance Induction in Islet Transplantation
por: Pathak, Shiva, et al.
Publicado: (2021)

Partial Loss of Nasal Tissue in a Facial Vascularized Composite Allograft Patient
por: Kauke, Martin, et al.
Publicado: (2020)

T-regulatory cell treatment prevents chronic rejection of heart allografts in a murine mixed chimerism model
por: Pilat, Nina, et al.
Publicado: (2014)

Posttransplant MRD and T-cell chimerism status predict outcomes in patients who received allografts for AML/MDS
por: Loke, Justin, et al.
Publicado: (2023)

Host-Based Th2 Cell Therapy for Prolongation of Cardiac Allograft Viability
por: Amarnath, Shoba, et al.
Publicado: (2011)

Prolonged Delayed Graft Function Is Associated with Inferior Patient and Kidney Allograft Survivals
por: de Sandes-Freitas, Tainá Veras, et al.
Publicado: (2015)

Abstract 37: Whole Eye Allograft Transplantation And Immunosuppression: Survival Of The Transplanted Rodent Eye Using Tacrolimus Monotherapy
por: Chen, Wendy, et al.
Publicado: (2018)

Prolonged survival of actively enhanced rat renal allografts despite accelerated cellular infiltration and rapid induction of both class I and class II MHC antigens
Publicado: (1987)

The Macrophage-depleting Agent Clodronate Promotes Durable Hematopoietic Chimerism and Donor-specific Skin Allograft Tolerance in Mice
por: Li, Zhanzhuo, et al.
Publicado: (2016)

Tolerance of a Vascularized Composite Allograft Achieved in MHC Class-I-mismatch Swine via Mixed Chimerism
por: Lellouch, Alexandre G., et al.
Publicado: (2022)

QT interval prolongation related to psychoactive drug treatment: a comparison of monotherapy versus polytherapy
por: Sala, Michela, et al.
Publicado: (2005)

Early innate immune events induced by prolonged cold ischemia exacerbate allograft vasculopathy
por: Devitt, Jennifer J, et al.
Publicado: (2011)

Fox smell abrogates the effect of herbal odor to prolong mouse cardiac allograft survival
por: Jin, Xiangyuan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_8b18cbhqg26m029srhf85hubuc