Therapeutic phosphorodiamidate morpholino oligonucleotides: Physical properties, solution structures, and folding thermodynamics

Elucidating the structure-function relationships for therapeutic RNA mimicking phosphorodiamidate morpholino oligonucleotides (PMOs) is challenging due to the lack of information about their structures. While PMOs have been approved by the US Food and Drug Administration for treatment of Duchenne mu...

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Detalles Bibliográficos
Autores principales: Maksudov, Farkhad, Kliuchnikov, Evgenii, Pierson, Daniel, Ujwal, M.L., Marx, Kenneth A., Chanda, Arani, Barsegov, Valeri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996446/
https://www.ncbi.nlm.nih.gov/pubmed/36910708
http://dx.doi.org/10.1016/j.omtn.2023.02.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996446/
https://www.ncbi.nlm.nih.gov/pubmed/36910708
http://dx.doi.org/10.1016/j.omtn.2023.02.007

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