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High-Throughput Exonuclease Assay Based on the Fluorescent Base Analogue 2-Aminopurine

[Image: see text] Exonucleases are essential enzymes that remove nucleotides from free DNA ends during DNA replication, DNA repair, and telomere maintenance. Due to their essential role, they are potential targets for novel anticancer and antimicrobial drugs but have so far been little exploited. He...

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Detalles Bibliográficos
Autores principales: Botto, Margherita M., Murthy, Sudarshan, Lamers, Meindert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996622/
https://www.ncbi.nlm.nih.gov/pubmed/36910963
http://dx.doi.org/10.1021/acsomega.2c06577