Synthesis of C3,C6-Diaryl 7-Azaindoles via One-Pot Suzuki–Miyaura Cross-Coupling Reaction and Evaluation of Their HIV-1 Integrase Inhibitory Activity

[Image: see text] There is a continuing demand of new inhibitors of HIV-1 Integrase (HIV-1 IN) due to mutations of HIV-1. This study aims to develop the synthesis of 3,6-diaryl 7-azaindoles and introspect the role of aryl groups on the strand transfer (ST) inhibition of HIV-1 IN. An efficient and ch...

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Detalles Bibliográficos
Autores principales: Cardoza, Savio, Yadav, Pooja, Ajmani, Abhishek, Das, Parthasarathi, Tandon, Vibha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996623/
https://www.ncbi.nlm.nih.gov/pubmed/36910947
http://dx.doi.org/10.1021/acsomega.2c07372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996623/
https://www.ncbi.nlm.nih.gov/pubmed/36910947
http://dx.doi.org/10.1021/acsomega.2c07372

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