Mechanistic modelling of tyrosine recombination reveals key parameters determining the performance of a CAR T cell switching circuit

Inducible genetic switches based on tyrosine recombinase‐based DNA excision are a promising platform for the regulation and control of chimeric antigen receptor (CAR) T cell activity in cancer immunotherapy. These switches exploit the increased stability of DNA excision in tyrosine recombinases thro...

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Detalles Bibliográficos
Autores principales: Bowyer, Jack E., Chakravarti, Deboki, Wong, Wilson W., Bates, Declan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Institution of Engineering and Technology 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996713/
https://www.ncbi.nlm.nih.gov/pubmed/36970230
http://dx.doi.org/10.1049/enb.2019.0020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996713/
https://www.ncbi.nlm.nih.gov/pubmed/36970230
http://dx.doi.org/10.1049/enb.2019.0020

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