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Mechanistic modelling of tyrosine recombination reveals key parameters determining the performance of a CAR T cell switching circuit
Inducible genetic switches based on tyrosine recombinase‐based DNA excision are a promising platform for the regulation and control of chimeric antigen receptor (CAR) T cell activity in cancer immunotherapy. These switches exploit the increased stability of DNA excision in tyrosine recombinases thro...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Institution of Engineering and Technology
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996713/ https://www.ncbi.nlm.nih.gov/pubmed/36970230 http://dx.doi.org/10.1049/enb.2019.0020 |