Dual Role of Glutathione as a Reducing Agent and Cu-Ligand Governs the ROS Production by Anticancer Cu-Thiosemicarbazone Complexes

[Image: see text] α-Pyridyl thiosemicarbazones (TSC) such as Triapine (3AP) and Dp44mT are a promising class of anticancer agents. Contrary to Triapine, Dp44mT showed a pronounced synergism with Cu(II), which may be due to the generation of reactive oxygen species (ROS) by Dp44mT-bound Cu(II) ions....

Descripción completa

Detalles Bibliográficos
Autores principales: Ritacca, Alessandra G., Falcone, Enrico, Doumi, Iman, Vileno, Bertrand, Faller, Peter, Sicilia, Emilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996813/
https://www.ncbi.nlm.nih.gov/pubmed/36802558
http://dx.doi.org/10.1021/acs.inorgchem.2c04392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996813/
https://www.ncbi.nlm.nih.gov/pubmed/36802558
http://dx.doi.org/10.1021/acs.inorgchem.2c04392

Ejemplares similares