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Dual Role of Glutathione as a Reducing Agent and Cu-Ligand Governs the ROS Production by Anticancer Cu-Thiosemicarbazone Complexes

[Image: see text] α-Pyridyl thiosemicarbazones (TSC) such as Triapine (3AP) and Dp44mT are a promising class of anticancer agents. Contrary to Triapine, Dp44mT showed a pronounced synergism with Cu(II), which may be due to the generation of reactive oxygen species (ROS) by Dp44mT-bound Cu(II) ions....

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Detalles Bibliográficos
Autores principales:	Ritacca, Alessandra G., Falcone, Enrico, Doumi, Iman, Vileno, Bertrand, Faller, Peter, Sicilia, Emilia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996813/ https://www.ncbi.nlm.nih.gov/pubmed/36802558 http://dx.doi.org/10.1021/acs.inorgchem.2c04392

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