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Investigating the Orientation of an Interfacially Adsorbed Monoclonal Antibody and Its Fragments Using Neutron Reflection

[Image: see text] Interfacial adsorption is a molecular process occurring during the production, purification, transport, and storage of antibodies, with a direct impact on their structural stability and subsequent implications on their bioactivities. While the average conformational orientation of...

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Detalles Bibliográficos
Autores principales: Ruane, Sean, Li, Zongyi, Hollowell, Peter, Hughes, Arwel, Warwicker, Jim, Webster, John R. P., van der Walle, Christopher F., Kalonia, Cavan, Lu, Jian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996827/
https://www.ncbi.nlm.nih.gov/pubmed/36795985
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00864