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Neurofibromatosis type 1-dependent alterations in mouse microglia function are not cell-intrinsic

We previously discovered a sex-by-genotype defect in microglia function using a heterozygous germline knockout mouse model of Neurofibromatosis type 1 (Nf1 ± mice), in which only microglia from male Nf1 ± mice exhibited defects in purinergic signaling. Herein, we leveraged an unbiased proteomic appr...

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Detalles Bibliográficos
Autores principales:	Logiacco, Francesca, Grzegorzek, Laura Cathleen, Cordell, Elizabeth C., Popp, Oliver, Mertins, Philipp, Gutmann, David H., Kettenmann, Helmut, Semtner, Marcus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996880/ https://www.ncbi.nlm.nih.gov/pubmed/36890585 http://dx.doi.org/10.1186/s40478-023-01525-w

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