Cargando…

Piperine improves the sensitivity of osteosarcoma cells to doxorubicin by inducing apoptosis and inhibiting the PI3K/AKT/GSK-3β pathway

BACKGROUND: Osteosarcoma is a primary bone malignancy associated with the highest incidence rate. Chemotherapy for osteosarcoma has not substantially changed, and survival of patients with metastatic tumours has reached a plateau. Doxorubicin (DOX) is a broad-spectrum anti-osteosarcoma drug; however...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qi, Yubin, Yao, Lin, Liu, Jianke, Wang, Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9996932/ https://www.ncbi.nlm.nih.gov/pubmed/36895009 http://dx.doi.org/10.1186/s13018-023-03642-7

Ejemplares similares

Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease
por: Kitagishi, Yasuko, et al.
Publicado: (2014)

Role of TLR4-Mediated PI3K/AKT/GSK-3β Signaling Pathway in Apoptosis of Rat Hepatocytes
por: Zhang, Xian, et al.
Publicado: (2015)

Phosphorylated GSK-3β protects stress-induced apoptosis of myoblasts via the PI3K/Akt signaling pathway
por: Liu, Meixi, et al.
Publicado: (2020)

Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways
por: Yao, Mingyan, et al.
Publicado: (2021)

Cryptotanshinone Induces Cell Cycle Arrest and Apoptosis of NSCLC Cells through the PI3K/Akt/GSK-3β Pathway
por: Kim, Sang-A, et al.
Publicado: (2018)

Inhibitory effect of oxymatrine on hepatocyte apoptosis via TLR4/PI3K/Akt/GSK-3β signaling pathway
por: Zhang, Xian, et al.
Publicado: (2017)

Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway
por: Chen, Hanyu, et al.
Publicado: (2020)

PCMT1 regulates the migration, invasion, and apoptosis of prostate cancer through modulating the PI3K/AKT/GSK-3β pathway
por: Zhong, Jiacheng, et al.
Publicado: (2023)

Prostaglandin F2α protects against pericyte apoptosis by inhibiting the PI3K/Akt/GSK3β/β-catenin signaling pathway
por: Cheng, Ying, et al.
Publicado: (2021)

Piperine protects against myocardial ischemia/reperfusion injury by activating the PI3K/AKT signaling pathway
por: Li, Yun-Peng, et al.
Publicado: (2021)

Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses
por: Matsuda, Satoru, et al.
Publicado: (2019)

Puerarin pretreatment attenuates cardiomyocyte apoptosis induced by coronary microembolization in rats by activating the PI3K/Akt/GSK-3β signaling pathway
por: Chen, Zhi-Qing, et al.
Publicado: (2021)

CXCR4 blockade sensitizes osteosarcoma to doxorubicin by inducing autophagic cell death via PI3K-Akt-mTOR pathway inhibition
por: Liao, Yu-Xin, et al.
Publicado: (2021)

Involvement of GSK-3β Phosphorylation Through PI3-K/Akt in Cerebral Ischemia-Induced Neurogenesis in Rats
por: Kisoh, Keishi, et al.
Publicado: (2016)

The Role of Insulin/IGF-1/PI3K/Akt/GSK3β Signaling in Parkinson's Disease Dementia
por: Yang, Liying, et al.
Publicado: (2018)

Calycosin induces apoptosis in osteosarcoma cell line via ERβ-mediated PI3K/Akt signaling pathways
por: Tian, Wei, et al.
Publicado: (2020)

Overstimulation can create health problems due to increases in PI3K/Akt/GSK3 insensitivity and GSK3 activity
por: Liu, Xunxian
Publicado: (2014)

Role of PI3K/Akt/GSK-3 Pathway in Emesis and Potential New Antiemetics
por: Zhong, W, et al.
Publicado: (2020)

Leonurine protects cardiac function following acute myocardial infarction through anti-apoptosis by the PI3K/AKT/GSK3β signaling pathway
por: Xu, Lin, et al.
Publicado: (2018)

Isoquercitrin Inhibits Hydrogen Peroxide-Induced Apoptosis of EA.hy926 Cells via the PI3K/Akt/GSK3β Signaling Pathway
por: Zhu, Meixia, et al.
Publicado: (2016)

Avenanthramide C Prevents Neuronal Apoptosis via PI3K/Akt/GSK3β Signaling Pathway Following Middle Cerebral Artery Occlusion
por: Jin, Baoyuan, et al.
Publicado: (2020)

Breviscapine Pretreatment Inhibits Myocardial Inflammation and Apoptosis in Rats After Coronary Microembolization by Activating the PI3K/Akt/GSK-3β Signaling Pathway
por: Chen, Zhi-Qing, et al.
Publicado: (2021)

Resveratrol Pretreatment Inhibits Myocardial Apoptosis in Rats Following Coronary Microembolization via Inducing the PI3K/Akt/GSK-3β Signaling Cascade
por: Li, Tao, et al.
Publicado: (2021)

Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK-3β Signaling Pathway to Improve Cognitive Impairment in Alzheimer's Disease Mice
por: Peng, Yan, et al.
Publicado: (2022)

Depletion of peroxiredoxin II promotes keratinocyte apoptosis and alleviates psoriatic skin lesions via the PI3K/AKT/GSK3β signaling axis
por: Han, Ying-Hao, et al.
Publicado: (2023)

Aloin induced apoptosis by enhancing autophagic flux through the PI3K/AKT axis in osteosarcoma
por: He, Jiaming, et al.
Publicado: (2021)

Yangxin granules alleviate doxorubicin-induced cardiotoxicity by suppressing oxidative stress and apoptosis mediated by AKT/GSK3β/β-catenin signaling
por: Ren, Dezhi, et al.
Publicado: (2020)

Piperine Induces Apoptosis and Autophagy in HSC-3 Human Oral Cancer Cells by Regulating PI3K Signaling Pathway
por: Han, Eun-Ji, et al.
Publicado: (2023)

Suppression of Virulent Porcine Epidemic Diarrhea Virus Proliferation by the PI3K/Akt/GSK-3α/β Pathway
por: Kong, Ning, et al.
Publicado: (2016)

Sulforaphane Ameliorates the Intestinal Injury in Necrotizing Enterocolitis by Regulating the PI3K/Akt/GSK-3β Signaling Pathway
por: Bao, Zhong-Kun, et al.
Publicado: (2022)

Salvigenin Suppresses Hepatocellular Carcinoma Glycolysis and Chemoresistance Through Inactivating the PI3K/AKT/GSK-3β Pathway
por: Shao, Hui, et al.
Publicado: (2023)

Activation of PI3K/Akt mediates the protective effect of diallyl trisulfide on doxorubicin induced cardiac apoptosis
por: Wen, Su-Ying, et al.
Publicado: (2023)

Recombinant Osteopontin Improves Neurological Functional Recovery and Protects Against Apoptosis via PI3K/Akt/GSK-3β Pathway Following Intracerebral Hemorrhage
por: Zhang, Wenqian, et al.
Publicado: (2018)

Sappanone A alleviates hypoxia/reoxygenation-induced cardiomyocytes injury through inhibition of mitochondrial apoptosis and activation of PI3K–Akt–Gsk-3β pathway
por: Shi, Xiaojing, et al.
Publicado: (2020)

Asafoetida exerts neuroprotective effect on oxidative stress induced apoptosis through PI3K/Akt/GSK3β/Nrf2/HO-1 pathway
por: Huang, Qianqian, et al.
Publicado: (2022)

[Corrigendum] Leonurine protects cardiac function following acute myocardial infarction through anti‑apoptosis by the PI3K/AKT/GSK3β signaling pathway
por: Xu, Lin, et al.
Publicado: (2023)

β-Escin inhibits the proliferation of osteosarcoma cells via blocking the PI3K/Akt pathway
por: Zhu, Minyu, et al.
Publicado: (2018)

Aldose Reductase Inhibition Prevents Allergic Airway Remodeling through PI3K/AKT/GSK3β Pathway in Mice
por: Yadav, Umesh C. S., et al.
Publicado: (2013)

Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson's Disease: Involvement of the PI3K/Akt/GSK3β Pathway
por: Zhang, Wei, et al.
Publicado: (2016)

Kaempferide Protects against Myocardial Ischemia/Reperfusion Injury through Activation of the PI3K/Akt/GSK-3β Pathway
por: Wang, Dong, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_urk1irp18r2lgljk94ho9qvr2t