APE1 promotes non-homologous end joining by initiating DNA double-strand break formation and decreasing ubiquitination of artemis following oxidative genotoxic stress

BACKGROUND: Apurinic/apyrimidinic endonuclease 1 (APE1) imparts radio-resistance by repairing isolated lesions via the base excision repair (BER) pathway, but whether and how it is involved in the formation and/or repair of DSBs remains mostly unknown. METHODS: Immunoblotting, fluorescent immunostai...

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Detalles Bibliográficos
Autores principales: Zhang, Qin, Yang, Lujie, Gao, Han, Kuang, Xunjie, Xiao, He, Yang, Chen, Cheng, Yi, Zhang, Lei, Guo, Xin, Zhong, Yong, Li, Mengxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997026/
https://www.ncbi.nlm.nih.gov/pubmed/36894994
http://dx.doi.org/10.1186/s12967-023-04022-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997026/
https://www.ncbi.nlm.nih.gov/pubmed/36894994
http://dx.doi.org/10.1186/s12967-023-04022-9

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