Cargando…

Glial cell transcriptome analyses in 3xTg-AD mice: Effects of aging, disease progression, and anti-Aβ immunotherapy

BACKGROUND: To investigate how changes in expression of glial genes relate to a progression of Alzheimer’s disease (AD) pathology, and how anti-Aβ immunotherapy impact these changes, we conducted a transcriptomic analysis for brains from cohorts of 2-, 10-, and 20 month old 3xTg-AD mice, and a cross...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lambracht-Washington, Doris, Fu, Min, Manouchehri, Navid, Hynan, Linda S., Stuve, Olaf, Rosenberg, Roger N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997156/ https://www.ncbi.nlm.nih.gov/pubmed/36911262 http://dx.doi.org/10.1016/j.nbas.2023.100066

Ejemplares similares

Changes in the brain transcriptome after DNA Aβ42 trimer immunization in a 3xTg-AD mouse model
por: Lambracht-Washington, Doris, et al.
Publicado: (2020)

Active full-length DNA Aβ(42) immunization in 3xTg-AD mice reduces not only amyloid deposition but also tau pathology
por: Rosenberg, Roger N., et al.
Publicado: (2018)

Olfactory dysfunction in the 3xTg-AD model of Alzheimer’s disease
por: Mitrano, Darlene A., et al.
Publicado: (2021)

Dopaminergic dysfunction in the 3xTg-AD mice model of Alzheimer’s disease
por: Gloria, Yesica, et al.
Publicado: (2021)

Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice
por: Giménez-Llort, Lydia, et al.
Publicado: (2010)

Impaired Spatial Reorientation in the 3xTg-AD Mouse Model of Alzheimer’s Disease
por: Stimmell, Alina C., et al.
Publicado: (2019)

Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer’s Disease
por: Javonillo, Dominic I., et al.
Publicado: (2022)

Abnormal whisker movements in the 3xTg‐AD mouse model of Alzheimer's disease
por: Simanaviciute, Ugne, et al.
Publicado: (2022)

Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice
por: Chen, Yanxing, et al.
Publicado: (2014)

Temporal and regional progression of Alzheimer’s disease‐like pathology in 3xTg‐AD mice
por: Belfiore, Ramona, et al.
Publicado: (2018)

Neuroprotective Effects of Probiotic-Supplemented Diet on Cognitive Behavior of 3xTg-AD Mice
por: Tan, Chenxi, et al.
Publicado: (2022)

Progressive Vascular Abnormalities in the Aging 3xTg-AD Mouse Model of Alzheimer’s Disease
por: Jullienne, Amandine, et al.
Publicado: (2022)

Anti-amyloid-beta to tau-based immunization: developments in immunotherapy for Alzheimer’s disease
por: Lambracht-Washington, Doris, et al.
Publicado: (2013)

Cognitive Impairment in the 3xTg-AD Mouse Model of Alzheimer’s Disease is Affected by Aβ-ImmunoTherapy and Cognitive Stimulation
por: Roda, Alejandro R., et al.
Publicado: (2020)

Treatment of Alzheimer's Disease with Anti-Homocysteic Acid Antibody in 3xTg-AD Male Mice
por: Hasegawa, Tohru, et al.
Publicado: (2010)

DHA Improves Cognition and Prevents Dysfunction of Entorhinal Cortex Neurons in 3xTg-AD Mice
por: Arsenault, Dany, et al.
Publicado: (2011)

Early and sustained altered expression of aging-related genes in young 3xTg-AD mice
por: Gatta, V, et al.
Publicado: (2014)

Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice
por: Van der Jeugd, Ann, et al.
Publicado: (2018)

Sex Differences in Healthspan Predict Lifespan in the 3xTg-AD Mouse Model of Alzheimer’s Disease
por: Kane, Alice E., et al.
Publicado: (2018)

Exercise and resveratrol increase fracture resistance in the 3xTg-AD mouse model of Alzheimer’s disease
por: Alkhouli, Mustafa F., et al.
Publicado: (2019)

Enhanced susceptibility of triple transgenic Alzheimer’s disease (3xTg-AD) mice to acute infection
por: Montacute, Rebecca, et al.
Publicado: (2017)

Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer’s Disease
por: Fagan, Steven G., et al.
Publicado: (2022)

Sexual Dimorphism in the 3xTg-AD Mouse Model and Its Impact on Pre-Clinical Research
por: Dennison, Jessica L., et al.
Publicado: (2021)

Retracted: Neuroprotective Effects of Probiotic-Supplemented Diet on Cognitive Behavior of 3xTg-AD Mice
por: Engineering, Journal of Healthcare
Publicado: (2023)

Endogenous Amyloid-formed Ca(2+)-permeable Channels in Aged 3xTg AD Mice
por: Li, Shuangtao, et al.
Publicado: (2023)

Low-Dose Chidamide Treatment Displays Sex-Specific Differences in the 3xTg-AD Mouse
por: Dennison, Jessica, et al.
Publicado: (2023)

Mesenchymal Stem Cells Preserve Working Memory in the 3xTg-AD Mouse Model of Alzheimer’s Disease
por: Ruzicka, Jiri, et al.
Publicado: (2016)

Sex-dependent alterations in the physiology of entorhinal cortex neurons in old heterozygous 3xTg-AD mice
por: Arsenault, Dany, et al.
Publicado: (2020)

Effects of the Novel IDO Inhibitor DWG-1036 on the Behavior of Male and Female 3xTg-AD Mice
por: Fertan, Emre, et al.
Publicado: (2019)

Microglial Activation in the Retina of a Triple-Transgenic Alzheimer’s Disease Mouse Model (3xTg-AD)
por: Salobrar-García, Elena, et al.
Publicado: (2020)

Inhibition of AMD-Like Pathology With a Neurotrophic Compound in Aged Rats and 3xTg-AD Mice
por: Liu, Yinghua, et al.
Publicado: (2019)

Differences in Immune-Related Genes Underlie Temporal and Regional Pathological Progression in 3xTg-AD Mice
por: Fernandes, Adelaide, et al.
Publicado: (2022)

The Effects of Physical Running on Dendritic Spines and Amyloid-beta Pathology in 3xTg-AD Male Mice
por: Xu, Benke, et al.
Publicado: (2022)

Attenuation of HECT-E3 ligase expression rescued memory deficits in 3xTg-AD mice
por: Suresh, Pavithra, et al.
Publicado: (2022)

Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer’s disease
por: Robison, Lisa S., et al.
Publicado: (2023)

Reducing AD-Like Pathology in 3xTg-AD Mouse Model by DNA Epitope Vaccine — A Novel Immunotherapeutic Strategy
por: Movsesyan, Nina, et al.
Publicado: (2008)

Effects of Dietary Supplementation of Carnosine on Mitochondrial Dysfunction, Amyloid Pathology, and Cognitive Deficits in 3xTg-AD Mice
por: Corona, Carlo, et al.
Publicado: (2011)

β-Secretase 1’s Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice
por: Piedrahita, Diego, et al.
Publicado: (2016)

Neuroprotective effects of bee venom phospholipase A2 in the 3xTg AD mouse model of Alzheimer’s disease
por: Ye, Minsook, et al.
Publicado: (2016)

Supragranular Pyramidal Cells Exhibit Early Metabolic Alterations in the 3xTg-AD Mouse Model of Alzheimer’s Disease
por: Piquet, Juliette, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_frvocmhnemt9icq7b4kgp9mvpk