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Early memory deficits and extensive brain network disorganization in the App(NL-F)/MAPT double knock-in mouse model of familial Alzheimer’s disease
A critical challenge in current research on Alzheimer’s disease (AD) is to clarify the relationship between network dysfunction and the emergence of subtle memory deficits in itspreclinical stage. The AppNL-F/MAPT double knock-in (dKI) model with humanized β-amyloid peptide (Aβ) and tau was used to...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997176/ https://www.ncbi.nlm.nih.gov/pubmed/36908877 http://dx.doi.org/10.1016/j.nbas.2022.100042 |