Abnormal mechanical stress on bicuspid aortic valve induces valvular calcification and inhibits Notch1/NICD/Runx2 signal

BACKGROUND: Bicuspid aortic valve (BAV) is a congenital cardiac deformity, increasing the risk of developing calcific aortic valve disease (CAVD). The disturbance of hemodynamics can induce valvular calcification, but the mechanism has not been fully identified. METHODS: We constructed a finite elem...

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Detalles Bibliográficos
Autores principales: Li, Guangzhou, Shen, Na, Deng, Huifang, Wang, Yixuan, Kong, Gangcheng, Shi, Jiawei, Dong, Nianguo, Deng, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2023
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997191/
https://www.ncbi.nlm.nih.gov/pubmed/36908813
http://dx.doi.org/10.7717/peerj.14950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997191/
https://www.ncbi.nlm.nih.gov/pubmed/36908813
http://dx.doi.org/10.7717/peerj.14950

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