Initiation and modulation of Tau protein phase separation by the drug suramin

Tau is an intrinsically disordered neuronal protein in the central nervous system. Aggregated Tau is the main component of neurofibrillary tangles observed in Alzheimer’s disease. In vitro, Tau aggregation can be triggered by polyanionic co-factors, like RNA or heparin. At different concentration ra...

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Detalles Bibliográficos
Autores principales: Prince, Prabhu Rajaiah, Hochmair, Janine, Brognaro, Hévila, Gevorgyan, Susanna, Franck, Maximilian, Schubert, Robin, Lorenzen, Kristina, Yazici, Selin, Mandelkow, Eckhard, Wegmann, Susanne, Betzel, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997437/
https://www.ncbi.nlm.nih.gov/pubmed/36894559
http://dx.doi.org/10.1038/s41598-023-29846-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9997437/
https://www.ncbi.nlm.nih.gov/pubmed/36894559
http://dx.doi.org/10.1038/s41598-023-29846-9

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